After 17 seasons in the MLB, in which he was one of the best players in the league, Lou Gehrig ended his illustrious career on May 2, 1939 when he took himself out of the New York Yankees lineup in a game against the Detroit Tigers. Gehrig felt weakened through the first month of the 1939 season and fellow players remember him not playing like he always had. Although he did not know it at the time, Lou Gehrig had amyotrophic later sclerosis (ALS), which would later be referred to as Lou Gehrig’s Disease. Although he died two years later in 1941, his career will forever be remembered. Gehrig was the first MLB player to have his uniform number retired.